Will I regain weight after stopping GLP-1 peptides?

Studies show significant weight regain typically occurs after discontinuing GLP-1 medications, with patients regaining an average of 0.8 kg per month and returning to baseline weight within approximately 18 months. A 2025 meta-analysis found semaglutide and tirzepatide users regained nearly 10 kg within the first year after stopping. This regain occurs regardless of lifestyle interventions, which is why current medical guidance emphasizes either continued therapy or implementing robust diet and exercise habits before discontinuation.