What is the standard semaglutide dosing schedule for weight loss?

The FDA-approved titration protocol for semaglutide (Wegovy) involves a gradual 16-week escalation: 0.25mg weekly for 4 weeks, then 0.5mg, 1mg, and 1.7mg for 4 weeks each, before reaching the 2.4mg maintenance dose. This slow titration is critical because semaglutide alters digestion and appetite signaling, and increasing too quickly can cause significant gastrointestinal side effects. Clinical trials demonstrated an average 14.9% body weight reduction over 68 weeks at the maintenance dose.