How long should I stay on GLP-1 peptides for weight loss?

According to 2025 WHO guidelines, GLP-1 therapies are recommended as long-term treatment for obesity, with a minimum of 6 months continuous use. Clinical trials have studied treatment durations ranging from 26 weeks to nearly 5 years. Because weight regain commonly occurs after discontinuation, most medical guidelines now consider GLP-1 medications a chronic therapy rather than short-term intervention, with duration determined individually based on response and tolerability.