How does retatrutide work differently than other weight loss peptides?

Retatrutide is a triple agonist that activates three receptors simultaneously: GLP-1, GIP, and glucagon. This triple mechanism reduces appetite, increases insulin sensitivity, and boosts energy expenditure through enhanced fat oxidation. Phase 3 clinical trials in 2025 showed participants achieved up to 24.2% mean body weight reduction at 48 weeks, with additional benefits including improved liver fat reduction and cardiovascular markers.