Can weight loss peptides be combined with muscle-building peptides?

Some practitioners explore combining GLP-1 agonists like semaglutide with growth hormone-releasing peptides such as CJC-1295/Ipamorelin or Sermorelin. The rationale is that GLP-1 peptides reduce appetite and support metabolic efficiency while growth hormone peptides may help preserve lean muscle mass during weight loss. However, this approach is largely off-label and experimental, and FDA-approved GLP-1 medications like semaglutide require medical supervision due to potential side effects including gallbladder problems and blood sugar changes.