How do GHRP and GHRH peptides work together in a stack?

GHRP (Growth Hormone Releasing Peptides) and GHRH (Growth Hormone Releasing Hormone) analogs work through different receptor pathways that produce synergistic effects when combined. GHRPs like Ipamorelin or GHRP-2 act on the ghrelin receptor (GHS-R1a) to increase GH pulse amplitude, while GHRH analogs like CJC-1295 enhance both the size and frequency of GH pulses through the GHRH receptor. Research indicates these peptides are most effective when administered in a fasted state, as food intake can suppress their activity through somatostatin signaling.