How do sleep peptides compare to melatonin supplements?

While melatonin works as a single hormone to signal sleep timing, peptides like DSIP and Epitalon regulate multiple pathways simultaneously, including supporting natural melatonin production and enhancing slow-wave sleep architecture. Research shows Epitalon increased midnight melatonin levels by 145% compared to pre-treatment levels in clinical studies. Peptides address underlying sleep mechanisms rather than providing temporary symptom relief, though they require longer timeframes (1-3 weeks) to show effects and medical supervision is recommended.