How do growth hormone releasing peptides affect sleep patterns?

Growth hormone (GH) is secreted in pulses primarily during deep slow-wave sleep, and growth hormone releasing peptides (GHRPs) like GHRP-2 and GHRP-6 stimulate this natural release pattern. Some research suggests these peptides may enhance sleep architecture and nighttime GH pulses, potentially improving sleep quality and recovery. However, clinical studies have shown mixed results, with some finding only modest effects on stage II sleep without significant changes to slow-wave or REM sleep. The combination of GHRPs with GHRH analogs is being studied for potential synergistic effects on both GH secretion and sleep optimization.