What should be considered for long-term peptide use?

Long-term peptide therapy requires ongoing medical supervision to monitor for potential effects such as immunogenicity, where the body may develop antibodies against the peptide that could reduce its effectiveness over time. Most FDA-approved therapeutic peptides have established safety profiles for extended use, but research peptides lack formal long-term safety data. Because peptides are metabolized into amino acids through natural pathways, accumulation toxicity is generally not a concern, though growth hormone-related peptides warrant monitoring due to their effects on IGF-1 levels.