What peptides are being researched for tendon and ligament injuries?

BPC-157 and TB-500 are the most studied peptides for musculoskeletal injuries in preclinical research. BPC-157 has shown promise in animal studies by enhancing fibroblast proliferation and collagen synthesis through FAK-paxillin signaling pathways, while also increasing growth hormone receptor expression in tendon tissue. TB-500, a synthetic fragment of Thymosin Beta-4, supports tissue repair through improved cell migration and angiogenesis. However, human clinical trials remain limited, and neither peptide is FDA-approved for therapeutic use.