How does TB-500 (Thymosin Beta-4) promote tissue repair?

TB-500 is a synthetic peptide based on Thymosin Beta-4, a naturally occurring 43-amino-acid protein found in nearly all human cells. Its primary mechanism involves high-affinity binding to G-actin, regulating actin polymerization which is essential for cellular migration and tissue repair. Research has shown TB-500 promotes angiogenesis through VEGF upregulation, and in wound healing studies, topical application increased re-epithelialization by up to 61% compared to controls while also enhancing collagen deposition.