What makes ipamorelin unique for stimulating growth hormone release?

Ipamorelin is a pentapeptide that acts as a selective agonist of the ghrelin/growth hormone secretagogue receptor (GHS-R), triggering rapid GH pulses from the pituitary gland. What distinguishes ipamorelin from other growth hormone secretagogues is its exceptional selectivity - it stimulates GH release without significantly affecting cortisol, ACTH, or prolactin levels, even at doses over 200-fold higher than effective GH-releasing doses. This selectivity profile, similar to natural GHRH, makes it the first truly selective GHRP-receptor agonist identified in research.