Why are CJC-1295 and ipamorelin often combined together?

CJC-1295 and ipamorelin work through complementary receptor pathways - CJC-1295 acts on GHRH receptors while ipamorelin activates ghrelin receptors - creating a synergistic effect that amplifies growth hormone secretion beyond what either peptide achieves alone. Research suggests this combination can produce a 3-5 fold increase in GH release compared to ipamorelin alone by both strengthening each GH pulse and increasing the number of hormone-secreting somatotroph cells. The pairing also combines ipamorelin's rapid 2-hour action with CJC-1295's extended 6-8 day half-life, providing both immediate and sustained GH elevation.